Wang Lab
Publications
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Chang M, Wang JC. Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis. Endocr Rev. 2025 Sep 2:bnaf030. doi: 10.1210/endrev/bnaf030. Epub ahead of print. PMID: 40892984.
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Chang M, Zhao M, Whang EM, Lee RA, Scott DK, Wang JC. The sphingosine-1-phosphate receptor 2 S1PR2 mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia. J Biol Chem. 2025 Jul;301(7):110353. doi: 10.1016/j.jbc.2025.110353. Epub 2025 Jun 7. PMID: 40490140; PMCID: PMC12274751.
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Lee, R. A., Chang, M., Tsay, A., Lee, Y. R., Li, D., Yiv, N., Tian, S., Zhao, M., O'Brien, R. M., & Wang, J. C. (2023). Chronic Glucocorticoid Exposure Induced a S1PR2-RORγ Axis to Enhance Hepatic Gluconeogenesis in Male Mice. Diabetes, db220605. Advance online publication. https://doi.org/10.2337/db22-0605
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Lee RA, Chang M, Yiv N, Tsay A, Tian S, Li D, Poulard C, Stallcup MR, Pufall MA, Wang JC. Transcriptional coactivation by EHMT2 restricts glucocorticoid-induced insulin resistance in a study with male mice. Nat Commun. 2023 May 30;14(1):3143. doi: 10.1038/s41467-023-38584-5. PubMed PMID: 37253782; PubMed Central PMCID: PMC10229547.
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Azhagiya Singam ER, Durkin KA, La Merrill MA, Furlow JD, Wang JC, Smith MT. The vitamin D receptor as a potential target for the toxic effects of per- and polyfluoroalkyl substances (PFASs): An in-silico study. Environ Res. 2023 Jan 15;217:114832. doi: 10.1016/j.envres.2022.114832. Epub 2022 Nov 18. PubMed PMID: 36403651; PubMed Central PMCID: PMC10044465.
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Yoo HS, Rodriguez A, You D, Lee RA, Cockrum MA, Grimes JA, Wang JC, Kang S, Napoli JL. The glucocorticoid receptor represses, whereas C/EBPβ can enhance or repress CYP26A1 transcription. iScience. 2022 Jul 15;25(7):104564. doi: 10.1016/j.isci.2022.104564. eCollection 2022 Jul 15. PubMed PMID: 35789854; PubMed Central PMCID: PMC9249609.
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Herber CB, Yuan C, Chang A, Wang JC, Cohen I, Leitman DC. 2',3',4'-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism. Mol Med. 2022 Apr 25;28(1):44. doi: 10.1186/s10020-022-00470-z. PubMed PMID: 35468719; PubMed Central PMCID: PMC9036729.
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Chen TC, Kuo T, Dandan M, Lee RA, Chang M, Villivalam SD, Liao SC, Costello D, Shankaran M, Mohammed H, Kang S, Hellerstein MK, Wang JC. The role of striated muscle Pik3r1 in glucose and protein metabolism following chronic glucocorticoid exposure. J Biol Chem. 2021 Jan-Jun;296:100395. doi: 10.1016/j.jbc.2021.100395. Epub 2021 Feb 7. PubMed PMID: 33567340; PubMed Central PMCID: PMC8010618.
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Castriota F, Zushin PH, Sanchez SS, Phillips RV, Hubbard A, Stahl A, Smith MT, Wang JC, La Merrill MA. Chronic arsenic exposure impairs adaptive thermogenesis in male C57BL/6J mice. Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E667-E677. doi: 10.1152/ajpendo.00282.2019. Epub 2020 Feb 11. PubMed PMID: 32045263; PubMed Central PMCID: PMC7272725.
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Castriota F, Rieswijk L, Dahlberg S, La Merrill MA, Steinmaus C, Smith MT, Wang JC. A State-of-the-Science Review of Arsenic's Effects on Glucose Homeostasis in Experimental Models. Environ Health Perspect. 2020 Jan;128(1):16001. doi: 10.1289/EHP4517. Epub 2020 Jan 3. Review. PubMed PMID: 31898917; PubMed Central PMCID: PMC7015542.
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Chen TC, Lee RA, Tsai SL, Kanamaluru D, Gray NE, Yiv N, Cheang RT, Tan JH, Lee JY, Fitch MD, Hellerstein MK, Wang JC. An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. J Biol Chem. 2019 Jun 7;294(23):9213-9224. doi: 10.1074/jbc.RA118.006259. Epub 2019 May 3. PubMed PMID: 31053639; PubMed Central PMCID: PMC6556567.
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McQueen AE, Koliwad SK, Wang JC. Fighting obesity by targeting factors regulating beige adipocytes. Curr Opin Clin Nutr Metab Care. 2018 Nov;21(6):437-443. doi: 10.1097/MCO.0000000000000509. Review. PubMed PMID: 30148740; PubMed Central PMCID: PMC6196736.
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Lee RA, Harris CA, Wang JC. Glucocorticoid Receptor and Adipocyte Biology. Nucl Receptor Res. 2018;5. doi: 10.32527/2018/101373. PubMed PMID: 30310815; PubMed Central PMCID: PMC6177265.
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Lee RA, Wang JC. Angiopoietin-like 4 in glucocorticoid induced insulin resistance. Oncotarget. 2017 Dec 5;8(63):106143-106144. doi: 10.18632/oncotarget.21294. eCollection 2017 Dec 5. PubMed PMID: 29290923; PubMed Central PMCID: PMC5739708.
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McQueen AE, Kanamaluru D, Yan K, Gray NE, Wu L, Li ML, Chang A, Hasan A, Stifler D, Koliwad SK, Wang JC. The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure. J Biol Chem. 2017 Sep 29;292(39):16122-16134. doi: 10.1074/jbc.M117.803973. Epub 2017 Aug 24. PubMed PMID: 28842503; PubMed Central PMCID: PMC5625043.
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Chen TC, Benjamin DI, Kuo T, Lee RA, Li ML, Mar DJ, Costello DE, Nomura DK, Wang JC. The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. Sci Signal. 2017 Jul 25;10(489). doi: 10.1126/scisignal.aai7905. PubMed PMID: 28743803; PubMed Central PMCID: PMC6218395.
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Kuo T, Chen TC, Lee RA, Nguyen NHT, Broughton AE, Zhang D, Wang JC. Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. Diabetes. 2017 Jun;66(6):1601-1610. doi: 10.2337/db16-0831. Epub 2017 Mar 14. PubMed PMID: 28292967; PubMed Central PMCID: PMC5440017.
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Boortz KA, Syring KE, Lee RA, Dai C, Oeser JK, McGuinness OP, Wang JC, O'Brien RM. G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance. Endocrinology. 2016 Nov;157(11):4133-4145. doi: 10.1210/en.2016-1678. Epub 2016 Sep 21. PubMed PMID: 27653037; PubMed Central PMCID: PMC5086534.
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Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM. G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14. PubMed PMID: 27300767; PubMed Central PMCID: PMC4967123.
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Kuo T, Liu PH, Chen TC, Lee RA, New J, Zhang D, Lei C, Chau A, Tang Y, Cheung E, Wang JC. Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes. Am J Physiol Endocrinol Metab. 2016 Apr 1;310(7):E572-85. doi: 10.1152/ajpendo.00214.2015. Epub 2016 Jan 12. PubMed PMID: 26758684; PubMed Central PMCID: PMC4824139.
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Kuo T, McQueen A, Chen TC, Wang JC. Regulation of Glucose Homeostasis by Glucocorticoids. Adv Exp Med Biol. 2015;872:99-126. doi: 10.1007/978-1-4939-2895-8_5. Review. PubMed PMID: 26215992; PubMed Central PMCID: PMC6185996.
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Granner DK, Wang JC, Yamamoto KR. Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms. Adv Exp Med Biol. 2015;872:3-31. doi: 10.1007/978-1-4939-2895-8_1. Review. PubMed PMID: 26215988.
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Ou CY, Chen TC, Lee JV, Wang JC, Stallcup MR. Coregulator cell cycle and apoptosis regulator 1 (CCAR1) positively regulates adipocyte differentiation through the glucocorticoid signaling pathway. J Biol Chem. 2014 Jun 13;289(24):17078-86. doi: 10.1074/jbc.M114.548081. Epub 2014 May 8. PubMed PMID: 24811171; PubMed Central PMCID: PMC4059149.
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Kuo T, Chen TC, Yan S, Foo F, Ching C, McQueen A, Wang JC. Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin. J Lipid Res. 2014 May;55(5):919-28. doi: 10.1194/jlr.M047860. Epub 2014 Feb 24. PubMed PMID: 24565756; PubMed Central PMCID: PMC3995469.
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Poole DP, Lee M, Tso P, Bunnett NW, Yo SJ, Lieu T, Shiu A, Wang JC, Nomura DK, Aponte GW. Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15;306(8):G686-98. doi: 10.1152/ajpgi.00433.2013. Epub 2014 Feb 27. PubMed PMID: 24578341; PubMed Central PMCID: PMC3989702.
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Kuo T, Harris CA, Wang JC. Metabolic functions of glucocorticoid receptor in skeletal muscle. Mol Cell Endocrinol. 2013 Nov 5;380(1-2):79-88. doi: 10.1016/j.mce.2013.03.003. Epub 2013 Mar 21. Review. PubMed PMID: 23523565; PubMed Central PMCID: PMC4893778.
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Kuo T, Lew MJ, Mayba O, Harris CA, Speed TP, Wang JC. Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11160-5. doi: 10.1073/pnas.1111334109. Epub 2012 Jun 25. PubMed PMID: 22733784; PubMed Central PMCID: PMC3396543.
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Koliwad SK, Gray NE, Wang JC. Angiopoietin-like 4 (Angptl4): A glucocorticoid-dependent gatekeeper of fatty acid flux during fasting. Adipocyte. 2012 Jul 1;1(3):182-187. doi: 10.4161/adip.20787. PubMed PMID: 23700531; PubMed Central PMCID: PMC3609093.
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Wang JC, Gray NE, Kuo T, Harris CA. Regulation of triglyceride metabolism by glucocorticoid receptor. Cell Biosci. 2012 May 28;2(1):19. doi: 10.1186/2045-3701-2-19. PubMed PMID: 22640645; PubMed Central PMCID: PMC3419133.
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Gray NE, Lam LN, Yang K, Zhou AY, Koliwad S, Wang JC. Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes. J Biol Chem. 2012 Mar 9;287(11):8444-56. doi: 10.1074/jbc.M111.294124. Epub 2012 Jan 19. PubMed PMID: 22267746; PubMed Central PMCID: PMC3318686.
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Yu CY, Mayba O, Lee JV, Tran J, Harris C, Speed TP, Wang JC. Genome-wide analysis of glucocorticoid receptor binding regions in adipocytes reveal gene network involved in triglyceride homeostasis. PLoS One. 2010 Dec 20;5(12):e15188. doi: 10.1371/journal.pone.0015188. PubMed PMID: 21187916; PubMed Central PMCID: PMC3004788.
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Shipp LE, Lee JV, Yu CY, Pufall M, Zhang P, Scott DK, Wang JC. Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids. PLoS One. 2010 Oct 29;5(10):e13754. doi: 10.1371/journal.pone.0013754. PubMed PMID: 21060794; PubMed Central PMCID: PMC2966426.
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Roohk DJ, Varady KA, Turner SM, Emson CL, Gelling RW, Shankaran M, Lindwall G, Shipp LE, Scanlan TS, Wang JC, Hellerstein MK. Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone. J Pharmacol Exp Ther. 2010 Apr;333(1):281-9. doi: 10.1124/jpet.109.162487. Epub 2010 Jan 11. PubMed PMID: 20065017.
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Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC. Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. J Biol Chem. 2009 Sep 18;284(38):25593-601. doi: 10.1074/jbc.M109.025452. Epub 2009 Jul 23. PubMed PMID: 19628874; PubMed Central PMCID: PMC2757961.
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Wang JC, Shah N, Pantoja C, Meijsing SH, Ho JD, Scanlan TS, Yamamoto KR. Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev. 2006 Mar 15;20(6):689-99. doi: 10.1101/gad.1400506. PubMed PMID: 16543221; PubMed Central PMCID: PMC1413289.
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Wang JC. Finding primary targets of transcriptional regulators. Cell Cycle. 2005 Mar;4(3):356-8. doi: 10.4161/cc.4.3.1521. Epub 2005 Mar 5. Review. PubMed PMID: 15711128.
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Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR. Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15603-8. doi: 10.1073/pnas.0407008101. Epub 2004 Oct 22. PubMed PMID: 15501915; PubMed Central PMCID: PMC524211.
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Wang JC, Walker A, Blackwell TK, Yamamoto KR. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004 Jul 9;279(28):29270-7. doi: 10.1074/jbc.M401242200. Epub 2004 Apr 8. PubMed PMID: 15073178.
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Rogatsky I, Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq CM, Darimont BD, Garabedian MJ, Yamamoto KR. Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13845-50. doi: 10.1073/pnas.2336092100. Epub 2003 Nov 14. PubMed PMID: 14617768; PubMed Central PMCID: PMC283509.
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Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. J Biol Chem. 2000 Jun 16;275(24):18418-23. doi: 10.1074/jbc.M910211199. PubMed PMID: 10748198.
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Wang JC, Stafford JM, Scott DK, Sutherland C, Granner DK. The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis. J Biol Chem. 2000 May 12;275(19):14717-21. doi: 10.1074/jbc.275.19.14717. PubMed PMID: 10799560.
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Sugiyama T, Wang JC, Scott DK, Granner DK. Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene. J Biol Chem. 2000 Feb 4;275(5):3446-54. doi: 10.1074/jbc.275.5.3446. PubMed PMID: 10652338.
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Wang JC, Strömstedt PE, Sugiyama T, Granner DK. The phosphoenolpyruvate carboxykinase gene glucocorticoid response unit: identification of the functional domains of accessory factors HNF3 beta (hepatic nuclear factor-3 beta) and HNF4 and the necessity of proper alignment of their cognate binding sites. Mol Endocrinol. 1999 Apr;13(4):604-18. doi: 10.1210/mend.13.4.0269. PubMed PMID: 10194766.
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Yamada K, Duong DT, Scott DK, Wang JC, Granner DK. CCAAT/enhancer-binding protein beta is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter. J Biol Chem. 1999 Feb 26;274(9):5880-7. doi: 10.1074/jbc.274.9.5880. PubMed PMID: 10026211.
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Wang JC, Stafford JM, Granner DK. SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J Biol Chem. 1998 Nov 20;273(47):30847-30850. doi: 10.1074/jbc.273.47.30847. PubMed PMID: 9812974; PubMed Central PMCID: PMC3968904.
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Sugiyama T, Scott DK, Wang JC, Granner DK. Structural requirements of the glucocorticoid and retinoic acid response units in the phosphoenolpyruvate carboxykinase gene promoter. Mol Endocrinol. 1998 Oct;12(10):1487-98. doi: 10.1210/mend.12.10.0187. PubMed PMID: 9773973.
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Yamada K, Wang JC, Osawa H, Scott DK, Granner DK. Efficient large-scale transformation of yeast. Biotechniques. 1998 Apr;24(4):596-8, 600. doi: 10.2144/98244bm19. PubMed PMID: 9564532.
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Scott DK, Strömstedt PE, Wang JC, Granner DK. Further characterization of the glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene. The role of the glucocorticoid receptor-binding sites. Mol Endocrinol. 1998 Apr;12(4):482-91. doi: 10.1210/mend.12.4.0090. PubMed PMID: 9544984.
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Wang JC, Strömstedt PE, O'Brien RM, Granner DK. Hepatic nuclear factor 3 is an accessory factor required for the stimulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Mol Endocrinol. 1996 Jul;10(7):794-800. doi: 10.1210/mend.10.7.8813720. PubMed PMID: 8813720.
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O'Brien RM, Noisin EL, Suwanichkul A, Yamasaki T, Lucas PC, Wang JC, Powell DR, Granner DK. Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes. Mol Cell Biol. 1995 Mar;15(3):1747-58. doi: 10.1128/MCB.15.3.1747. PubMed PMID: 7532283; PubMed Central PMCID: PMC230399.
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